The following day she got diarrhea and was extreemly quiet. Took him to the vet Potassium level was so high they did an ekg and his heart was not beating regular. My dog died from it after one dose within 24 hours. Millions of dogs take flea and heartworm meds without side effects but that's not to say it doesn't happen or that an alternative would be safer. Needless to say, we will no longer be giving this to our lab or our other dog. Use a collar or topical if you need to. She's pacing and wants to eat grass. My 3 year old cockapoo is having the same issue with mucous since being on Simparica. The FDA has approved this product for use in dogs between 5.6 and 11 pounds 1. Then she lost control of her legs and couldn't walk or stand. I left a lot out but didnt want to make too lengthy post. About 11 months ago our vet recommended Simparica Trio. The doctor did blood work and gave him steroids and said to watch him carefully for the next few days. They keep telling me that she would have been sick from the first pill, not just the 2nd. Getting him to go out was nearly impossible. In other words, they can make it easier to have a seizure in susceptible dogs. Product Details: Simparica Trio Chewables for dogs. They gave him a strong shot of prednisone that was good for 2 days . But I noticed that I had to "wake him' several times in only 2 minutes time, but he wasn't sleeping, his eyes were open and I saw them rolling in the back of his head! With the March 1 dose, on that day, I noticed him seeming to be very fearful and flinching on several occasions. I dont want to have to put my dog down but hes suffering. Billy Boy is a 9 week old Daisy Dog. I feel like it was a massive overdose. My French bulldog 2 years olds had a second attack in 3 days. Im praying over him too . Our pups had been on next guard and heart guard with no issues but new vet stopped selling those products so switched to to the simparica trio - gave a dose to our 7 ur old 71 pound blue tick coonhound Frazier and our 10 mo 45 pound labradoodle- Watson. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. First month, the one threw up, same thing second month. I started thinking about his history. Side effects are uncommon, but may occur in some cases. But he had a terrifying seizure when I was out walking him on December 26, 2020 with no previous known history (he is rescue I've had since he was 2). My Jack Russell Terrier has taken Simparica Trio for several months. and lack of appetite. I also am seeking information as to if there is a class action suit against this company because there should be. I lost my girl 2 days after taking Simparica. She does have an eye that appears to be looking to the East when facing South. She nearly died. He is starting to get better. Banfield Hospital pushed" Simparica Trio" on our 16 year old Toy Poodle which caused a neurological disorder of sundowner to the point of him having two days straight of constant seizures, repetitive pacing and extreme agitation. After second pill, weve notice he has been a bit down for a couple days. Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. Hey carol im so sorry to hear about your dog? Clinical Pharmacology In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. This all-in-one tablet can help make it easier to keep pesky parasites away this spring (and all year long). Gave my 3 month old, 3 pound shih tzu simparica on Sunday night. I hope yours is an isolated incident! I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. We administered the first dose on Wednesday June 1st to our 9 year old bouvier flanders. We took him to the animal er and they checked his vitals and he was fine. Simparica has caused my 12 pound 5 year old Jack Russel Terrior mix to have leg tremors and have trouble walking, jumping, or running. Some had fleas, some had heartworms, and some had roundworms. Oh Lord, back to finding another vet. Gastrointestinal Issues: Some dogs may experience diarrhea, vomiting, or a decreased appetite after taking Simparica Trio. Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. She probabpy had some in her system (which is quite common, even for well-cated-for puppies), which would explain her diarrhea. After about a week, she started to improve. However, the product has not been evaluated in breeding, pregnant, or lactating dogs. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. Two quick questionsDo the dogs eventually return to normal? It seemed impossible that our boy could age years in literally 3 days. 300+ Cute Cat Names for Every Kind of Kitty. This neurotoxin destroys fleas, ticks, and other insects for 35 days after your dog takes the medicine. She has NEVER done that before. I have reached out to the company but one email bounced and the other was an online form. She gave her a shot to keep her from throwing up and took her x-rays and told me to come back the next day if she wasn't better. Her blood work came back fine. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. Now it is March, on Tuesday I gave him his de-wormer and Wednesday he had a seizure. No more of this poison for him. This was the only thing we changed, I am convinced this is what did it to her. He also had a blood test done and all was normal. They both got similar issues and this was the only thing they both did. Simparica has been approved by the FDA to treat and prevent flea and tick infestations. He was a dog you could pick up anytime and he was good as gold. It's not worth the risk of additional seizures or other neurological effects, and it seems that his stumbling and getting tired sooner on walks are likely related. But this month we are at day 7 and I expect the diarrhea it to continue. I dont like the idea if ingestible medicine that kills fleas. Will be talking to the vet inregards to his side effects. Especially, Camelia who lost her furbaby because of a seizure that was apparently brought on by this medication. Simparica Trio comes with a customer satisfaction guarantee: Zoetis will cover some or all vet expenses should your dog develop heartworm disease, Lyme disease, a flea infestation, hookworms, or roundworms. The vet just gave our 16lb shorkie this on Tuesday and he still has the tremors really bad and very lethargic, Im very worried and concerned. Plan to take him to see the vet tomorrow. Gave Simparica yesterday and am suspect. I read all the above and it makes me sad. Needless, to say I will not be giving them the simparica trio again. Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. Skin issues. The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. Side effects include: vomiting, diarrhea, lethargy, anorexia, otitis externa (ear. I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . I called our Vet on the second day and they said they doubted very seriously that the Simparica would have give him diarrhea, and then told me that I should wait and see what happens with the next dose, because I had also told them that he had some drippings from some ground beef over his dog food the day before I gave him that first dose. I will update once we have results from diagnostics. Simparica Trio: A One-Stop-Solution For Parasites. These signs usually resolve without treatment. My sincere sympathies to those with horrendous seizure side effects. And both of my other labs, basically house dogs, ended up with a droopy left eye. My 11 year old terrier mix has been weak, uncoordinated and pacing up and down the hallway most of the day, sometimes stopping and staring at the wall. Any advice on the diarrhea? Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. She has had tremors, very lethargic, drinking lots of water. Her protein levels dropped to almost nothing and stomach filled with fluid. She has been the healthiest, happiest dog. And how long for this sheet to get out of the dogs system??? I will never give this again! Not to worry you, and I hope yours is different outcome! A few months back he started with a morning vomiting always on his empty tummy. All we want to do is take the best care of our animals and trust the people (Vet's) who specialize in this to do what's right for them. He is back to his old self now but we will never give him this medication again. Thank you for giving information on what happened to your dog. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. I am terrified--wish I would of seen this sooner. I did some research and because he seemed otherwise fine, I assumed it was "small white dog" shaking due to his breed mix. The vet doesn't seem to really want to blame it on Simperica Trio and wants to treat these symptoms which he says are life threatening. He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. This is because it doesn't kill adult heartworms. We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. Dogs Naturally Market is a good source to check out. She's finally resting at home, but still not able to walk, run, eat, etc. Our pup only made it 4 months after her first seizure, but this did seem to help her symptoms toward the end. Initially I noticed minor tremors and twitching when he slept or was just relaxing. So scary. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. The third ingredient in Simparica Trio is. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). We think that the drug is the cause of the seizures . By overloading chloride into these worms, it affects the electrical activity within their nervous system, causing muscle paralysis and death. She walks around as if she is on ice with no control of her back legs. I took him to the energy vet in the morning, he couldnt find any cause for pain, only he yelped a bit on his neck, they had trouble getting him in, he was yanking his neck around as he is afraid of the vet since getting fixed. I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! I am so worried after reading these comments. My vet never informed me of any issues with this medication and I'm kicking myself hard now after reading all of these horrible experiences with everyone's fur companions. I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. My heart is broken. Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. Flea and tick infestations make too lengthy post we took him to the vet inregards to his effects! 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